Laboratory of Cellular and Tissue Physiology

Department of Developmental Biology, Stanford University School of Medicine

We try to understand the fundamental principles of how biological systems maintain function over time, and why resilience eventually fails with age. Bridging engineering, computation, and biology, we develop and apply  technologies to map and control resilience mechanisms across multiple scales within living animals. Ultimately, we aim to create novel interventions that enhance resilience, slow aging-related decline, or even restore lost function.

We study how biological systems maintain function despite stress and damage. By systematically mapping molecular and cellular mechanisms, we aim to identify key pathways that protect cells and tissues throughout life. This will reveal how resilience mechanisms are coordinated across cell types, adapt to environmental challenges, and fail with age.

Reading & Writing Biology

We develop new technologies to measure and manipulate genes and cells at an unprecedentedly high resolution and large scale in living animals. By integrating imaging, functional genomics, and AI, we aim to systematically understand how genetic and environmental factors shape cellular function within intact tissues, and to program new functionalities into cells in vivo.

Engineering Cells & Tissues